Ozempic demonstrated remarkable anti-aging effects in a randomized controlled trial involving 108 people with HIV-associated lipohypertrophy, a condition characterized by excess fat accumulation and accelerated cellular aging.
The researchers used epigenetic clocks to assess biological aging and found that those on semaglutide became 3.1 years biologically younger on average by the end of the study.
The anti-aging effects weren’t uniform across all body systems – the most dramatic improvements occurred in the inflammatory system and brain. The researchers believe that the anti-aging properties of semaglutide stem from its effects on fat distribution and metabolic health.
Read the article on MedPath.
Sources:
• TLDR. (2025, August 6). TLDR Newsletter. https://a.tldrnewsletter.com/web-version?ep=1&lc=f5cb7e17-003d-11ed-9258-0241b9615763&p=f92ec73c-7297-11f0-b62f-25ab05113243&pt=campaign&t=1754477890&s=280ecaa4ef82310a651c4e04fb32d74945d83da746d498bd9268486092e8973c
• MedPath – Medical Intelligence Platform. (2025, August 1). MedPath. https://trial.medpath.com/news/5c43f09ebb6d0f8e/ozempic-shows-anti-aging-effects-in-first-clinical-trial-reversing-biological-age-by-3-1-years
